Muscarinic receptor subtypes: implications for lung disease.
نویسنده
چکیده
منابع مشابه
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
Up to date, there are four pharmacologically characterized subtypes of muscarinic receptors (M1, M2, M3 and M4). In our study we have investigated muscarinic receptor subtypes in smooth muscle layers of human stomach. Isolated preparations of longitudinal and circular muscle layers from human stomach were used. Acetylcholine, bethanechol, carbachol, pilocarpine and AHR -602 produced concen...
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In the airways, increases in cholinergic nerve activity and cholinergic hypersensitivity are associated with chronic obstructive pulmonary disease and asthma. However, the contribution of individual muscarinic acetylcholine receptor subtypes to the constriction of smaller intrapulmonary airways that are primarily responsible for airway resistance has not been analyzed. To address this issue, we...
متن کاملBiological behaviors of muscarinic receptors in mesenchymal stem cells derived from human placenta and bone marrow
Objective(s): Cells perform their functional activities by communicating with each other through endogenous substances and receptors. Post-translation, stem cells function properly in new host tissue by carrying specific cell surface receptors. We aimed to characterize muscarinic receptor subtypes in mesenchymal stem cells (MSCs) together with osteogenic and adipogenic...
متن کاملEffect of 2-(acetyloxy)-N,N,N-trimethylpropan-1-aminium on Tracheal Smooth Muscle Reactivity
Muscarinic receptor subtypes have been identified on airways of several mammalian species, including humans. M1-receptors are found in airway ganglia, M2-receptors (autoreceptors) are present in cholinergic postganglionic nerves at the prejunctional level, whereas the muscarinic receptor subtypes found in airway smooth muscle are of the M3-receptor subtype (1, 12). Methacholine 2-(acetyloxy)-N,...
متن کاملMuscarinic acetylcholine receptors in the lung.
5 genetically distinct subtypes of muscarinic acetylcholine receptors have been cloned from human and rat tissues [l, 2 , 31 and these have been dubbed ml, m2, m3, m4 and m5. Each individual subtype has been expressed in animal cells and their pharmacology determined (4). It appears that the pharmacological subtypes Ml, M2 and M3 correspond to the cloned subtypes ml, m2 and m3. However, m4 and ...
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عنوان ژورنال:
- Thorax
دوره 44 3 شماره
صفحات -
تاریخ انتشار 1989